1g/Foil Antineoplastic Powder Doxorubicin HCl with Competitve Price
2018-08-15 12:03:43
Model NO.: 25316-40-9
Product Name: Doxorubicin HCl
CAS: 25316-40-9
Appearance: Orange-Red or Red Crystalline Powder
Mf: C27h30clno11
MW: 579.98
Einecs: 246-818-3
Trademark: Simeiquan
Transport Package: 0.001kg/Foil or as Require
Specification: ISO9001
Origin: China
HS Code: 3001200020
Doxorubicin hydrochloride
CAS: 25316-40-9
MF: C27H30ClNO11
MW: 579.98
EINECS: 246-818-3
Synonyms: ADRIACIN;ADRIBLASTINA;ADRIBLASTINA HYDROCHLORIDE;ADRIAMYCIN HCL;ADRIAMYCIN HYDROCHLORIDE;(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;14-HYDROXYDAUNOMYCIN HCL;14-HYDROXYDAUNOMYCIN HYDROCHLORIDE
Appearance:Orange-red or red crystalline powder
Chemical Properties Orange-Red Crystalline Solid
Usage Used as an antineoplastic
Usage Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
Usage Antibacterial;DNA intercalant
Usage Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
General Description Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9.
Air & Water Reactions Water soluble.
Reactivity Profile Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard Doxorubicin hydrochloride is probably combustible.
Biological Activity Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.
| Items Tested | Specification | Result |
| Purity | 98.0~102.0% | 99.02% |
| Description |
Orange-red or red crystalline powder; No visible evidence of contamination by foreign matter. |
Confirm |
| Identification A | IR spectrum corresponds to the IR spectrum of the reference standard | Confirm |
| Identification B |
The retention time of the doxorubicin peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
Confirm |
| Solubility | Soluble in water and methanol; slightly soluble in ethanol; practically insoluble in acetone. | Conforms |
| Residual Solvents |
 |
 |
| Acetone | ≤ 0.5% | 0.31% |
| Acetone +Ethanol | ≤ 2.5% | 0.60% |
| methanol | ≤ 0.3% | Not detected |
| Dichloromethane | ≤ 0.06% | Not detected |
| pH | 4.0 to 5.5 | 5.1 |
| Water Content | ≤ 4.0% | 0.8% |
| Related Substances |
 |
 |
| Impurity A (Doxorubicinone) | ≤ 0.5% | 0.1% |
| Any Other unknown Impurity | ≤ 0.1% | 0.07% |
| Total unknown Impurities | ≤ 0.3% | 0.2% |
| Total Impurities | ≤ 1.0% | 0.9% |
| Conclusion | It complies to reference standard | |
Competitive Advantages:
1. Professional raw powder factory in China, all powders are factory directly supplying. Have over 10 years' honour.
2. We exported to all over the world such as Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and so on, over 100kgs each month.
3. Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
4. Our products and services will focus on the largest customer demand. We hold the greatest enthusiasm and sincere cooperation with each customer.
5. A discount would be given when you make a large order.
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